LGR5, leucine rich repeat containing G protein-coupled receptor 5

LGR5, leucine rich repeat containing G protein-coupled receptor 5

• The protein encoded by this gene is a leucine-rich repeat-containing receptor (LGR) and member of the G protein-coupled, 7-transmembrane receptor (GPCR) superfamily. The encoded protein is a receptor for R-spondins and is involved in the canonical Wnt signaling pathway. This protein plays a role in the formation and maintenance of adult intestinal stem cells during postembryonic development. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

• Gene Synonyms (leucine-rich repeat-containing G-protein coupled receptor 5, G-protein coupled receptor 49, G-protein coupled receptor 67, G-protein coupled receptor HG38, orphan G protein-coupled receptor HG38, FEX, GPR49, GPR67, GRP49, HG38,)
• NCBI Gene ID: 8549
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O75473
  UNIPROT ID#>>A0A0A8K8C7
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

leucine rich repeat containing G protein-coupled receptor 5 interacts with:

• R-spondin 2
  R-spondin 2
  zinc and ring finger 3
  zinc and ring finger 3

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.