P2RX6, purinergic receptor P2X 6

P2RX6, purinergic receptor P2X 6

• The protein encoded by this gene belongs to the family of P2X receptors, which are ATP-gated ion channels and mediate rapid and selective permeability to cations. This gene is predominantly expressed in skeletal muscle, and regulated by p53. The encoded protein is associated with VE-cadherin at the adherens junctions of human umbilical vein endothelial cells. Alternative splicing results in multiple transcript variants. A related pseudogene, which is also located on chromosome 22, has been identified. [provided by RefSeq, Apr 2009]

• Gene Synonyms (P2X purinoceptor 6, ATP receptor, purinergic receptor P2X, ligand gated ion channel, 6, purinergic receptor P2X-like 1, orphan receptor, purinoceptor P2X6, purinoreceptor P2X6, skeletal muscle-expressed P2X, P2RXL1, P2X6, P2XM,)
• NCBI Gene ID: 9127
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O15547
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

purinergic receptor P2X 6 interacts with:

• BAG cochaperone 5
  DnaJ heat shock protein family (Hsp40) member B4
  DnaJ heat shock protein family (Hsp40) member B5

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.