RGS6, regulator of G protein signaling 6

RGS6, regulator of G protein signaling 6

• This gene encodes a member of the RGS (regulator of G protein signaling) family of proteins, which are defined by the presence of a RGS domain that confers the GTPase-activating activity of these proteins toward certain G alpha subunits. This protein also belongs to a subfamily of RGS proteins characterized by the presence of DEP and GGL domains, the latter a G beta 5-interacting domain. The RGS proteins negatively regulate G protein signaling, and may modulate neuronal, cardiovascular, lymphocytic activities, and cancer risk. Many alternatively spliced transcript variants encoding different isoforms with long or short N-terminal domains, complete or incomplete GGL domains, and distinct C-terminal domains, have been described for this gene, however, the full-length nature of some of these variants is not known.[provided by RefSeq, Mar 2011]

• Gene Synonyms (regulator of G-protein signaling 6, regulator of G-protein signalling 6, GAP, HA117, S914,)
• NCBI Gene ID: 9628
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B7Z2A0
  UNIPROT ID#>>Q2M3K2
  UNIPROT ID#>>P49758
  UNIPROT ID#>>B7Z2N1
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

regulator of G protein signaling 6 interacts with:

• coiled-coil domain containing 85B
  DNA methyltransferase 1 associated protein 1
  G protein subunit beta 4
  G protein subunit beta 5
  stathmin 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.