- Gene Overview
- Interaction Network
- Sequence Verification
FIG4, FIG4 phosphoinositide 5-phosphatase
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The protein encoded by this gene belongs to the SAC domain-containing protein gene family. The SAC domain, approximately 400 amino acids in length and consisting of seven conserved motifs, has been shown to possess phosphoinositide phosphatase activity. The yeast homolog, Sac1p, is involved in the regulation of various phosphoinositides, and affects diverse cellular functions such as actin cytoskeleton organization, Golgi function, and maintenance of vacuole morphology. Membrane-bound phosphoinositides function as signaling molecules and play a key role in vesicle trafficking in eukaryotic cells. Mutations in this gene have been associated with Charcot-Marie-Tooth disease, type 4J. [provided by RefSeq, Jul 2008]
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Gene Synonyms (polyphosphoinositide phosphatase, FIG4 homolog, SAC domain containing lipid phosphatase, FIG4 homolog, SAC1 domain containing lipid phosphatase, FIG4 homolog, SAC1 lipid phosphatase domain containing, SAC domain-containing protein 3, Sac domain-containing inositol phosphatase 3, phosphatidylinositol 3,5-bisphosphate 5-phosphatase, ALS11, BTOP, CMT4J, KIAA0274, SAC3, YVS, dJ249I4.1,)
- NCBI Gene ID:
9896
- Species:
Homo sapiens (Human)
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UNIPROT ID#>>Q92562
- View the NCBI Database
for this Gene »
Gene products are often involved in multiple pathways and networks within a living
cell. Learn more about other interacting partners.
FIG4 phosphoinositide 5-phosphatase interacts with:
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