FOLH1, folate hydrolase 1

FOLH1, folate hydrolase 1

• This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms. [provided by RefSeq, Jul 2010]

• Gene Synonyms (FGCP, FOLH, GCP2, GCPII, NAALAD1, NAALAdase, PSM, PSMA, mGCP, glutamate carboxypeptidase 2, N-acetylated alpha-linked acidic dipeptidase 1, N-acetylated-alpha-linked acidic dipeptidase I, NAALADase I, cell growth-inhibiting gene 27 protein, folylpoly-gamma-glutamate carboxypeptidase, glutamate carboxylase II, glutamate carboxypeptidase II, membrane glutamate carboxypeptidase, prostate specific membrane antigen variant F, pteroylpoly-gamma-glutamate carboxypeptidase,)
• NCBI Gene ID: 2346
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q04609
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

folate hydrolase 1 interacts with:

• chromosome 3 open reading frame 52
  heterogeneous nuclear ribonucleoprotein L
  histone deacetylase 1
  histone deacetylase 1
  membrane metalloendopeptidase
  methylthioadenosine phosphorylase
  ribosomal protein S3

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.