- Gene Overview
- Interaction Network
- Sequence Verification
IGLL1, immunoglobulin lambda like polypeptide 1
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The preB cell receptor is found on the surface of proB and preB cells, where it is involved in transduction of signals for cellular proliferation, differentiation from the proB cell to the preB cell stage, allelic exclusion at the Ig heavy chain gene locus, and promotion of Ig light chain gene rearrangements. The preB cell receptor is composed of a membrane-bound Ig mu heavy chain in association with a heterodimeric surrogate light chain. This gene encodes one of the surrogate light chain subunits and is a member of the immunoglobulin gene superfamily. This gene does not undergo rearrangement. Mutations in this gene can result in B cell deficiency and agammaglobulinemia, an autosomal recessive disease in which few or no gamma globulins or antibodies are made. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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Gene Synonyms (immunoglobulin lambda-like polypeptide 1, CD179 antigen-like family member B, CD179b antigen, Pre-B lymphocyte-specific protein-2, ig lambda-5, immunoglobulin omega polypeptide chain, immunoglobulin-related 14.1 protein, immunoglobulin-related protein 14.1, lambda5, 14.1, AGM2, CD179b, IGL1, IGL5, IGLJ14.1, IGLL, IGO, IGVPB, VPREB2,)
- NCBI Gene ID:
3543
- Species:
Homo sapiens (Human)
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UNIPROT ID#>>P15814
- View the NCBI Database
for this Gene »
Gene products are often involved in multiple pathways and networks within a living
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immunoglobulin lambda like polypeptide 1 interacts with:
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