IL2RA, interleukin 2 receptor subunit alpha

IL2RA, interleukin 2 receptor subunit alpha

• The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency. The level of IL2/IL2R in plasma has been found to be elevated in some patients with severe COVID-19, but decreased in critical patients. [provided by RefSeq, Jun 2020]

• Gene Synonyms (interleukin-2 receptor subunit alpha, IL-2 receptor subunit alpha, IL-2R subunit alpha, TAC antigen, interleukin 2 receptor, alpha, CD25, IDDM10, IL2R, IMD41, TCGFR, p55,)
• NCBI Gene ID: 3559
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P01589
  UNIPROT ID#>>Q5W005
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

interleukin 2 receptor subunit alpha interacts with:

• hepatocyte growth factor-regulated tyrosine kinase substrate
  interleukin 2 receptor subunit alpha
  interleukin 2 receptor subunit beta
  nuclear factor kappa B subunit 1
  signal transducer and activator of transcription 3
  signal transducer and activator of transcription 5B
  syntrophin alpha 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.