IL17A, interleukin 17A

IL17A, interleukin 17A

• The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Jul 2008]

• Gene Synonyms (interleukin-17A, cytotoxic T-lymphocyte-associated antigen 8, cytotoxic T-lymphocyte-associated protein 8, interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8), CTLA-8, CTLA8, IL-17, IL-17A, IL17,)
• NCBI Gene ID: 3605
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q16552
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

interleukin 17A interacts with:

• dipeptidyl peptidase 8
  interleukin 17 receptor A
  interleukin 17A
  lon peptidase 2, peroxisomal
  potassium voltage-gated channel interacting protein 4
  thioredoxin domain containing 15
  TNF receptor associated factor 6
  TRAF3 interacting protein 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.