WFDC2, WAP four-disulfide core domain 2

WFDC2, WAP four-disulfide core domain 2

• This gene encodes a protein that is a member of the WFDC domain family. The WFDC domain, or WAP Signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is expressed in pulmonary epithelial cells, and was also found to be expressed in some ovarian cancers. The encoded protein is a small secretory protein, which may be involved in sperm maturation. [provided by RefSeq, Jul 2008]

• Gene Synonyms (EDDM4, HE4, WAP5, dJ461P17.6, WAP four-disulfide core domain protein 2, WAP domain containing protein HE4-V4, epididymal protein 4, epididymal secretory protein E4, epididymis secretory sperm binding protein, epididymis-specific, whey-acidic protein type, four-disulfide core, major epididymis-specific protein E4, putative protease inhibitor WAP5,)
• NCBI Gene ID: 10406
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q14508
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

WAP four-disulfide core domain 2 interacts with:

• ADP ribosylation factor like GTPase 13B
  BTB domain containing 1
  cAMP responsive element binding protein 3 like 1
  cartilage acidic protein 1
  coenzyme Q9
  complexin 4
  ER membrane protein complex subunit 4
  family with sequence similarity 209 member A
  FKBP prolyl isomerase 7
  golgin, RAB6 interacting
  IKBKB interacting protein
  pannexin 1
  protein disulfide isomerase family A member 5
  solute carrier family 22 member 23
  thioredoxin related transmembrane protein 2
  WD repeat domain 81
  WD repeat domain 91

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.