- Gene Overview
- Interaction Network
- Sequence Verification
IL1RAPL1, interleukin 1 receptor accessory protein like 1
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The protein encoded by this gene is a member of the interleukin 1 receptor family and is similar to the interleukin 1 accessory proteins. This protein has an N-terminal signal peptide, three extracellular immunoglobulin Ig-like domains, a transmembrane domain, an intracellular Toll/IL-1R domain, and a long C-terminal tail which interacts with multiple signalling molecules. This gene is located at a region on chromosome X that is associated with a non-syndromic form of X-linked intellectual disability. Deletions and mutations in this gene were found in patients with intellectual disability. This gene is expressed at a high level in post-natal brain structures involved in the hippocampal memory system, which suggests a specialized role in the physiological processes underlying memory and learning abilities, and plays a role in synapse formation and stabilization. [provided by RefSeq, Jul 2017]
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Gene Synonyms (interleukin-1 receptor accessory protein-like 1, X-linked interleukin-1 receptor accessory protein-like 1, interleukin 1 receptor-8, mental retardation, X-linked 10, oligophrenin-4, three immunoglobulin domain-containing IL-1 receptor-related 2, IL-1-RAPL-1, IL-1RAPL-1, IL1R8, IL1RAPL, IL1RAPL-1, MRX10, MRX21, MRX34, OPHN4, TIGIRR-2,)
- NCBI Gene ID:
11141
- Species:
Homo sapiens (Human)
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UNIPROT ID#>>X5DNQ7
UNIPROT ID#>>Q9NZN1
- View the NCBI Database
for this Gene »
Gene products are often involved in multiple pathways and networks within a living
cell. Learn more about other interacting partners.
interleukin 1 receptor accessory protein like 1 interacts with:
Paste a protein or nucleic acid sequence in the box below to confirm that it matches
this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see
how a sequence matches to an experimentally-validated ORF clone.
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