AP2S1, adaptor related protein complex 2 subunit sigma 1

AP2S1, adaptor related protein complex 2 subunit sigma 1

• One of two major clathrin-associated adaptor complexes, AP-2, is a heterotetramer which is associated with the plasma membrane. This complex is composed of two large chains, a medium chain, and a small chain. This gene encodes the small chain of this complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

• Gene Synonyms (AP-2 complex subunit sigma, HA2 17 kDa subunit, adaptor protein complex AP-2 subunit sigma, adaptor related protein complex 2 sigma 1 subunit, clathrin assembly protein 2 sigma small chain, clathrin coat assembly protein AP17, clathrin coat-associated protein AP17, clathrin-associated/assembly/adaptor protein, small 2 (17kD), plasma membrane adaptor AP-2 17 kDa protein, sigma2-adaptin, AP17, CLAPS2, FBH3, FBHOk, HHC3,)
• NCBI Gene ID: 1175
• Species: Homo sapiens (Human)
• UNIPROT ID#>>M0QYZ2
  UNIPROT ID#>>P53680
  UNIPROT ID#>>M0R0N4
  UNIPROT ID#>>X6R390
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

adaptor related protein complex 2 subunit sigma 1 interacts with:

• ADP ribosylation factor GTPase activating protein 1
  alpha and gamma adaptin binding protein
  AP2 associated kinase 1
  argonaute RISC catalytic component 2
  BMP2 inducible kinase
  centrosomal protein 128
  clathrin light chain B
  coiled-coil domain containing 32
  cullin 9
  dishevelled segment polarity protein 2
  DNA polymerase theta
  DnaJ heat shock protein family (Hsp40) member C5
  dynactin 3
  EPH receptor A2
  epidermal growth factor receptor
  epidermal growth factor receptor pathway substrate 15
  epidermal growth factor receptor pathway substrate 15 like 1
  estrogen receptor 2
  FCH and mu domain containing endocytic adaptor 2
  GC-rich promoter binding protein 1 like 1
  growth factor receptor bound protein 2
  IKBKB interacting protein
  integrin subunit alpha 4
  intersectin 1
  intersectin 2
  ketohexokinase
  mindbomb E3 ubiquitin protein ligase 1
  mitogen-activated protein kinase 6
  MYC proto-oncogene, bHLH transcription factor
  myosin VI
  NECAP endocytosis associated 2
  NUMB endocytic adaptor protein
  OCRL inositol polyphosphate-5-phosphatase
  p21 (RAC1) activated kinase 5
  RAB25, member RAS oncogene family
  ralA binding protein 1
  RALBP1 associated Eps domain containing 1
  RecQ like helicase 4
  ring finger protein 11
  ring finger protein 4
  ring finger protein 41
  RUN domain containing 3A
  smoothened, frizzled class receptor
  stonin 2
  teratocarcinoma-derived growth factor 1
  transmembrane protein 17
  tumor necrosis factor
  ubiquitin B
  ubiquitin C
  UTP25 small subunit processor component
  vascular cell adhesion molecule 1
  WD repeat domain, phosphoinositide interacting 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.