COL7A1, collagen type VII alpha 1 chain

COL7A1, collagen type VII alpha 1 chain

• This gene encodes the alpha chain of type VII collagen. The type VII collagen fibril, composed of three identical alpha collagen chains, is restricted to the basement zone beneath stratified squamous epithelia. It functions as an anchoring fibril between the external epithelia and the underlying stroma. Mutations in this gene are associated with all forms of dystrophic epidermolysis bullosa. In the absence of mutations, however, an acquired form of this disease can result from an autoimmune response made to type VII collagen. [provided by RefSeq, Jul 2008]

• Gene Synonyms (collagen alpha-1(VII) chain, LC collagen, collagen VII, alpha-1 polypeptide, collagen, type VII, alpha 1, long-chain collagen, EBD1, EBDCT, EBR1, NDNC8,)
• NCBI Gene ID: 1294
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q59F16
  UNIPROT ID#>>Q02388
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

collagen type VII alpha 1 chain interacts with:

• aurora kinase B
  F-box and leucine rich repeat protein 2
  fibronectin 1
  heat shock protein family A (Hsp70) member 8
  kinesin family member 19A
  laminin subunit alpha 1
  laminin subunit alpha 5
  laminin subunit beta 3
  laminin subunit gamma 2
  leucine rich repeat containing 57
  matrix metallopeptidase 2
  MIA SH3 domain ER export factor 3
  Mov10 RISC complex RNA helicase
  NFKB inhibitor alpha
  nuclear receptor interacting protein 3
  nuclear RNA export factor 1
  nucleoporin 214
  SH3KBP1 binding protein 1
  spire type actin nucleation factor 2
  synuclein alpha
  thrombospondin 1
  zinc finger CCCH-type containing 7A

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.