Fbn1, fibrillin 1

Fbn1, fibrillin 1

• This gene encodes a member of the fibrillin family of proteins. The encoded preproprotein is proteolytically processed to generate two proteins including the extracellular matrix component fibrillin-1 and the protein hormone asprosin. Fibrillin-1 is an extracellular matrix glycoprotein that serves as a structural component of calcium-binding microfibrils. Asprosin, secreted by white adipose tissue, has been shown to regulate glucose homeostasis. Homozygous knockout mice for this gene exhibit impaired aortic development and early postnatal death, which was attributed to a deficiency in the fibrillin-1 protein. Mice with a hypomorphic allele of this gene exhibit impaired glucose homeostasis, likely due to a reduction in serum asprosin levels. [provided by RefSeq, Apr 2016]

• (No alternate names found)
• NCBI Gene ID: 14118
• Species: Mus musculus (Mouse)
• UNIPROT ID#>>Q61554
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

fibrillin 1 interacts with:

• adhesion G protein-coupled receptor E5
  FK506 binding protein 7
  insulin-like growth factor binding protein 5
  laminin, alpha 2
  laminin, alpha 5
  latent transforming growth factor beta binding protein 1
  mannose receptor, C type 2
  microfibrillar associated protein 5
  plexin B2
  sulfatase modifying factor 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.