CYBB, cytochrome b-245 beta chain

CYBB, cytochrome b-245 beta chain

• Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell's respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole. [provided by RefSeq, Jul 2008]

• Gene Synonyms (cytochrome b-245 heavy chain, CGD91-phox, NADPH oxidase 2, cytochrome b(558) subunit beta, cytochrome b-245 beta polypeptide, cytochrome b558 subunit beta, heme-binding membrane glycoprotein gp91phox, neutrophil cytochrome b 91 kDa polypeptide, p22 phagocyte B-cytochrome, superoxide-generating NADPH oxidase heavy chain subunit, AMCBX2, CGD, GP91-1, GP91-PHOX, GP91PHOX, IMD34, NOX2, p91-PHOX,)
• NCBI Gene ID: 1536
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A0S2Z3S6
  UNIPROT ID#>>P04839
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

cytochrome b-245 beta chain interacts with:

• amyloid beta precursor protein binding protein 2
  cytochrome b-245 chaperone 1
  F-box and WD repeat domain containing 7
  IQ motif containing GTPase activating protein 1
  neutrophil cytosolic factor 1
  neutrophil cytosolic factor 2
  neutrophil cytosolic factor 4
  Rac family small GTPase 1
  TNF receptor superfamily member 1A

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