CYP1B1, cytochrome P450 family 1 subfamily B member 1

CYP1B1, cytochrome P450 family 1 subfamily B member 1

• This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The enzyme encoded by this gene localizes to the endoplasmic reticulum and metabolizes procarcinogens such as polycyclic aromatic hydrocarbons and 17beta-estradiol. Mutations in this gene have been associated with primary congenital glaucoma; therefore it is thought that the enzyme also metabolizes a signaling molecule involved in eye development, possibly a steroid. [provided by RefSeq, Jul 2008]

• Gene Synonyms (cytochrome P450 1B1, aryl hydrocarbon hydroxylase, cytochrome P450, family 1, subfamily B, polypeptide 1, cytochrome P450, subfamily I (dioxin-inducible), polypeptide 1 (glaucoma 3, primary infantile), dioxin-inducible cytochrome p450, flavoprotein-linked monooxygenase, hydroperoxy icosatetraenoate dehydratase, microsomal monooxygenase, xenobiotic monooxygenase, ASGD6, CP1B, CYPIB1, GLC3A, P4501B1,)
• NCBI Gene ID: 1545
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q16678
  UNIPROT ID#>>Q53TK1
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

cytochrome P450 family 1 subfamily B member 1 interacts with:

• E1A binding protein p300
  estrogen receptor 2
  H3 clustered histone 1
  heat shock protein family B (small) member 2
  progesterone receptor membrane component 1
  SUMO1 activating enzyme subunit 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.