DBI, diazepam binding inhibitor, acyl-CoA binding protein

DBI, diazepam binding inhibitor, acyl-CoA binding protein

• This gene encodes diazepam binding inhibitor, a protein that is regulated by hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain synapses. The protein is conserved from yeast to mammals, with the most highly conserved domain consisting of seven contiguous residues that constitute the hydrophobic binding site for medium- and long-chain acyl-Coenzyme A esters. Diazepam binding inhibitor is also known to mediate the feedback regulation of pancreatic secretion and the postprandial release of cholecystokinin, in addition to its role as a mediator in corticotropin-dependent adrenal steroidogenesis. Three pseudogenes located on chromosomes 6, 8 and 16 have been identified. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

• Gene Synonyms (acyl-CoA-binding protein, GABA receptor modulator, acyl coenzyme A binding protein, acyl-Coenzyme A binding domain containing 1, cholecystokinin-releasing peptide, trypsin-sensitive, diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein), diazepam binding inhibitor (GABA receptor modulator, acyl-Coenzyme A binding protein), diazepam-binding inhibitor, endozepine, epididymis secretory sperm binding protein, ACBD1, ACBP, CCK-RP, EP,)
• NCBI Gene ID: 1622
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P07108
  UNIPROT ID#>>B8ZWD8
  UNIPROT ID#>>B8ZWD1
  UNIPROT ID#>>A0A024RAF2
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

diazepam binding inhibitor, acyl-CoA binding protein interacts with:

• 3'-phosphoadenosine 5'-phosphosulfate synthase 1
  agrin
  centrosomal protein 135
  DNA damage inducible transcript 4 like
  dual specificity phosphatase 23
  galectin 3
  glycogen synthase kinase 3 beta
  heat shock protein family E (Hsp10) member 1
  intersectin 2
  late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
  MCL1 apoptosis regulator, BCL2 family member
  microtubule associated protein 1 light chain 3 beta
  nipsnap homolog 1
  NSFL1 cofactor
  phosphatidylethanolamine binding protein 1
  phosphopantothenoylcysteine decarboxylase
  prefoldin subunit 2
  protocadherin 1
  RAB26, member RAS oncogene family
  RAD23 homolog A, nucleotide excision repair protein
  RAD23 homolog B, nucleotide excision repair protein
  solute carrier family 25 member 32
  superoxide dismutase 1
  transmembrane protein 132A
  ubiquitin conjugating enzyme E2 N
  UBX domain protein 2A
  YKT6 v-SNARE homolog

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.