GSDME, gasdermin E

GSDME, gasdermin E

• Hearing impairment is a heterogeneous condition with over 40 loci described. The protein encoded by this gene is expressed in fetal cochlea, however, its function is not known. Nonsyndromic hearing impairment is associated with a mutation in this gene. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

• Gene Synonyms (gasdermin-E, DFNA5, deafness associated tumor suppressor, inversely correlated with estrogen receptor expression 1, non-syndromic hearing impairment protein 5, nonsyndromic hearing impairment protein, DFNA5, ICERE-1,)
• NCBI Gene ID: 1687
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024RA58
  UNIPROT ID#>>O60443
  UNIPROT ID#>>A4FVA8
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

gasdermin E interacts with:

• baculoviral IAP repeat containing 6
  EPH receptor A1
  epidermal growth factor receptor
  glycerol-3-phosphate acyltransferase 4
  golgi brefeldin A resistant guanine nucleotide exchange factor 1
  magnesium transporter MRS2
  mitochondrial E3 ubiquitin protein ligase 1
  neurotrophic receptor tyrosine kinase 1
  plectin
  pleiotrophin
  ribosomal protein S3
  RUS family member 1
  SIGLEC family like 1
  SNW domain containing 1
  sodium voltage-gated channel beta subunit 2
  solute carrier family 27 member 2
  TRAF interacting protein with forkhead associated domain
  zinc finger and SCAN domain containing 29

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.