DNA2, DNA replication helicase/nuclease 2

DNA2, DNA replication helicase/nuclease 2

• This gene encodes a member of the DNA2/NAM7 helicase family. The encoded protein is a conserved helicase/nuclease involved in the maintenance of mitochondrial and nuclear DNA stability. Mutations in this gene are associated with autosomal dominant progressive external ophthalmoplegia-6 (PEOA6) and Seckel syndrome 8. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]

• Gene Synonyms (DNA replication ATP-dependent helicase/nuclease DNA2, DNA replication ATP-dependent helicase-like homolog, DNA replication helicase 2 homolog, DNA2 DNA replication helicase 2-like, DNA2-like helicase, DNA2L, hDNA2,)
• NCBI Gene ID: 1763
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P51530
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

DNA replication helicase/nuclease 2 interacts with:

• 3-hydroxy-3-methylglutaryl-CoA reductase
  activating signal cointegrator 1 complex subunit 3
  A-kinase anchoring protein 11
  BORA aurora kinase A activator
  bromodomain containing 7
  catenin beta like 1
  cullin 4A
  cullin 4B
  cytosolic iron-sulfur assembly component 1
  cytosolic iron-sulfur assembly component 2B
  DnaJ heat shock protein family (Hsp40) member C7
  dynein light chain LC8-type 1
  E1A binding protein p300
  enhancer of zeste 2 polycomb repressive complex 2 subunit
  exonuclease 1
  FA complementation group D2
  FAT atypical cadherin 4
  flap structure-specific endonuclease 1
  glutamate-cysteine ligase modifier subunit
  HAUS augmin like complex subunit 7
  LYN proto-oncogene, Src family tyrosine kinase
  misato mitochondrial distribution and morphology regulator 1
  MMS19 homolog, cytosolic iron-sulfur assembly component
  Mov10 RISC complex RNA helicase
  NIN1 (RPN12) binding protein 1 homolog
  nuclear receptor binding protein 1
  nuclear RNA export factor 1
  plasminogen activator, urokinase receptor
  protein kinase C substrate 80K-H
  protein kinase cAMP-activated catalytic subunit beta
  RAD51 recombinase
  RB binding protein 8, endonuclease
  replication protein A1
  replication protein A2
  replication protein A3
  secretagogin, EF-hand calcium binding protein
  serine hydroxymethyltransferase 2
  SMG7 nonsense mediated mRNA decay factor
  threonyl-tRNA synthetase 3
  TNF receptor associated factor 6
  UPF1 RNA helicase and ATPase
  WASH complex subunit 2A

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.