FCGR2B, Fc fragment of IgG receptor IIb

FCGR2B, Fc fragment of IgG receptor IIb

• The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

• Gene Synonyms (CD32, CD32B, FCG2, FCGR2, FCGR2C, FcRII-c, IGFR2, low affinity immunoglobulin gamma Fc region receptor II-b, CDw32, Fc fragment of IgG, low affinity II, receptor for (CD32), Fc fragment of IgG, low affinity IIb, receptor (CD32), Fc fragment of IgG, low affinity IIb, receptor for (CD32), Fc gamma RIIb, Fc gamma receptor IIb, Fc-gamma RII-c, Fc-gamma-RIIc, IgG Fc receptor II-c, Low affinity immunoglobulin gamma Fc region receptor II-c, fc-gamma RII-b, fc-gamma-RIIb, fcRII-b, igG Fc receptor II-b,)
• NCBI Gene ID: 2213
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P31994
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

Fc fragment of IgG receptor IIb interacts with:

• ergosterol biosynthesis 28 homolog
  glycogen synthase kinase 3 alpha
  GRB2 associated binding protein 1
  growth factor receptor bound protein 2
  inositol polyphosphate phosphatase like 1
  inositol polyphosphate-5-phosphatase D
  lymphocyte antigen 6 family member E
  LYN proto-oncogene, Src family tyrosine kinase
  methionyl-tRNA synthetase 2, mitochondrial
  mitogen-activated protein kinase 1
  mitogen-activated protein kinase 3
  protein kinase C alpha
  protein tyrosine phosphatase non-receptor type 11
  protein tyrosine phosphatase non-receptor type 6
  SHC adaptor protein 1
  target of myb1 membrane trafficking protein

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.