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- Interaction Network
- Sequence Verification
SIGLEC8, sialic acid binding Ig like lectin 8
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Sialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. SIGLEC8 is a member of the CD33-like subgroup of SIGLECs, which are localized to 19q13.3-q13.4 and have 2 conserved cytoplasmic tyrosine-based motifs: an immunoreceptor tyrosine-based inhibitory motif, or ITIM (see MIM 604964), and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM; MIM 603492) that mediates an association with SLAM-associated protein (SAP; MIM 300490) (summarized by Foussias et al., 2000 [PubMed 11095983]).[supplied by OMIM, May 2010]
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Gene Synonyms (sialic acid-binding Ig-like lectin 8, CDw329, SAF-2, sialoadhesin family member 2, SAF2, SIGLEC-8, SIGLEC8L,)
- NCBI Gene ID:
27181
- Species:
Homo sapiens (Human)
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UNIPROT ID#>>Q9NYZ4
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for this Gene »
Gene products are often involved in multiple pathways and networks within a living
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sialic acid binding Ig like lectin 8 interacts with:
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