GLI1, GLI family zinc finger 1

GLI1, GLI family zinc finger 1

• This gene encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

• Gene Synonyms (zinc finger protein GLI1, GLI-Kruppel family member GLI1, glioma-associated oncogene 1, glioma-associated oncogene homolog 1 (zinc finger protein), oncogene GLI, GLI, PAPA8, PPD1,)
• NCBI Gene ID: 2735
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P08151
  UNIPROT ID#>>B4DNF7
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

GLI family zinc finger 1 interacts with:

• actin related protein 2/3 complex subunit 2
  allantoicase
  Aly/REF export factor
  beta-transducin repeat containing E3 ubiquitin protein ligase
  BUB3 mitotic checkpoint protein
  capping protein inhibiting regulator of actin dynamics
  cation channel sperm associated 1
  eukaryotic translation initiation factor 3 subunit I
  F-box and leucine rich repeat protein 17
  fem-1 homolog B
  FMR1 autosomal homolog 1
  G protein subunit alpha 13
  G protein subunit alpha i1
  G protein subunit beta 1
  GRIP and coiled-coil domain containing 1
  histone deacetylase 1
  histone deacetylase 2
  importin 7
  inhibitor of nuclear factor kappa B kinase subunit beta
  intraflagellar transport 74
  intraflagellar transport 81
  itchy E3 ubiquitin protein ligase
  itchy, E3 ubiquitin protein ligase
  kinesin family member 7
  lysine acetyltransferase 2B
  MRE11 homolog, double strand break repair nuclease
  MYC proto-oncogene, bHLH transcription factor
  nucleophosmin 1
  NUMB endocytic adaptor protein
  NUMB endocytic adaptor protein
  peptidylprolyl cis/trans isomerase, NIMA-interacting 1
  PGAM family member 5, mitochondrial serine/threonine protein phosphatase
  phenylalanyl-tRNA synthetase subunit beta
  pleckstrin homology domain containing A4
  prohibitin 2
  prolyl 4-hydroxylase subunit alpha 1
  protein arginine methyltransferase 5
  protein inhibitor of activated STAT 1
  protein kinase AMP-activated catalytic subunit alpha 1
  protein kinase AMP-activated catalytic subunit alpha 2
  protein kinase cAMP-activated catalytic subunit alpha
  protein phosphatase 1 catalytic subunit beta
  RAD50 double strand break repair protein
  receptor for activated C kinase 1
  retinoic acid induced 1
  ribosomal protein L21
  serine/threonine kinase 36
  Sin3A associated protein 18
  SMAD family member 2
  SMAD family member 4
  sonic hedgehog
  sorting nexin 33
  SUFU negative regulator of hedgehog signaling
  SUFU negative regulator of hedgehog signaling
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
  TATA-box binding protein associated factor 9
  tetratricopeptide repeat domain 26
  transcriptional regulator, SIN3A (yeast)
  tripartite motif containing 27
  tripartite motif containing 42
  tumor protein p53
  ubiquitin specific peptidase 21
  ubiquitin specific peptidase 37
  ubiquitin specific peptidase 48
  ubiquitin specific peptidase 7
  von Hippel-Lindau tumor suppressor
  WD repeat domain 77
  WD repeat domain 77
  X-box binding protein 1
  Zic family member 1
  Zic family member 2
  zinc finger MYM-type containing 3

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.