GP5, glycoprotein V platelet

GP5, glycoprotein V platelet

• Human platelet glycoprotein V (GP5) is a part of the Ib-V-IX system of surface glycoproteins that constitute the receptor for von Willebrand factor (VWF; MIM 613160) and mediate the adhesion of platelets to injured vascular surfaces in the arterial circulation, a critical initiating event in hemostasis. The main portion of the receptor is a heterodimer composed of 2 polypeptide chains, an alpha chain (GP1BA; MIM 606672) and a beta chain (GP1BB; MIM 138720), that are linked by disulfide bonds. The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX (GP9; MIM 173515) and GP5. Mutations in GP1BA, GP1BB, and GP9 have been shown to cause Bernard-Soulier syndrome (MIM 231200), a bleeding disorder (review by Lopez et al., 1998 [PubMed 9616133]).[supplied by OMIM, Nov 2010]

• Gene Synonyms (platelet glycoprotein V, glycoprotein 5, CD42d, GPV,)
• NCBI Gene ID: 2814
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P40197
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

glycoprotein V platelet interacts with:

• ring finger protein 123
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta

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