LAMTOR2, late endosomal/lysosomal adaptor, MAPK and MTOR activator 2

LAMTOR2, late endosomal/lysosomal adaptor, MAPK and MTOR activator 2

• The product of this gene is highly conserved with a mouse protein associated with the cytoplasmic face of late endosomes and lysosomes. The mouse protein interacts with MAPK scaffold protein 1, a component of the mitogen-activated protein kinase pathway. In humans, a mutation in this gene has been associated with a primary immunodeficiency syndrome, and suggests a role for this protein in endosomal biogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]

• Gene Synonyms (ragulator complex protein LAMTOR2, MAPBP-interacting protein, MAPKSP1 adaptor protein, endosomal adaptor protein p14, late endosomal/lysosomal Mp1-interacting protein, late endosomal/lysosomal adaptor and MAPK and MTOR activator 2, mitogen-activated protein-binding protein-interacting protein (MAPBPIP), roadblock domain containing 3, roadblock domain-containing protein 3, ENDAP, HSPC003, MAPBPIP, MAPKSP1AP, ROBLD3, Ragulator2, p14,)
• NCBI Gene ID: 28956
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9Y2Q5
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 interacts with:

• abhydrolase domain containing 11
  BLOC-1 related complex subunit 6
  copine 8
  dynein light chain roadblock-type 1
  late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
  late endosomal/lysosomal adaptor, MAPK and MTOR activator 4
  leucine rich repeat containing 59
  mitochondrial ribosomal protein S21
  Ras related GTP binding C
  Ras related GTP binding D
  regulatory associated protein of MTOR complex 1
  solute carrier family 38 member 9
  thioredoxin domain containing 12
  TP53 regulated inhibitor of apoptosis 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.