HABP2, hyaluronan binding protein 2

HABP2, hyaluronan binding protein 2

• This gene encodes a member of the peptidase S1 family of serine proteases. The encoded preproprotein is secreted by hepatocytes and proteolytically processed to generate heavy and light chains that form the mature heterodimer. Further autoproteolysis leads to smaller, inactive peptides. This extracellular protease binds hyaluronic acid and may play a role in the coagulation and fibrinolysis systems. Mutations in this gene are associated with nonmedullary thyroid cancer and susceptibility to venous thromboembolism. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]

• Gene Synonyms (hyaluronan-binding protein 2, factor VII activating protein, factor VII-activating protease, factor seven-activating protease, hepatocyte growth factor activator-like protein, hyaluronic acid binding protein 2, plasma hyaluronan binding protein, FSAP, HABP, HGFAL, NMTC5, PHBP,)
• NCBI Gene ID: 3026
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q14520
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

hyaluronan binding protein 2 interacts with:

• kininogen 1
  TNF alpha induced protein 3
  TRAF family member associated NFKB activator

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