CFH, complement factor H

CFH, complement factor H

• This gene is a member of the Regulator of Complement Activation (RCA) gene cluster and encodes a protein with twenty short consensus repeat (SCR) domains. This protein is secreted into the bloodstream and has an essential role in the regulation of complement activation, restricting this innate defense mechanism to microbial infections. Mutations in this gene have been associated with hemolytic-uremic syndrome (HUS) and chronic hypocomplementemic nephropathy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Oct 2011]

• Gene Synonyms (complement factor H, H factor 1 (complement), H factor 2 (complement), adrenomedullin binding protein, age-related maculopathy susceptibility 1, beta-1-H-globulin, beta-1H, factor H, factor H-like 1, AHUS1, AMBP1, ARMD4, ARMS1, CFHL3, FH, FHL1, HF, HF1, HF2, HUS,)
• NCBI Gene ID: 3075
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024R962
  UNIPROT ID#>>P08603
  UNIPROT ID#>>A0A0D9SG88
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

complement factor H interacts with:

• complement factor H related 1
  complement factor H related 3
  complement factor I
  integrin subunit alpha M
  kelch like family member 18
  methylmalonyl-CoA mutase
  pentraxin 3
  selectin L
  SMAD family member 3
  thrombospondin 1
  vitamin D receptor
  VPS16 core subunit of CORVET and HOPS complexes
  YTH domain containing 1
  zinc finger and BTB domain containing 16

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.