- Gene Overview
- Interaction Network
- Sequence Verification
HLA-DMA, major histocompatibility complex, class II, DM alpha
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HLA-DMA belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta chain (DMB), both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. [provided by RefSeq, Jul 2008]
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Gene Synonyms (HLA class II histocompatibility antigen, DM alpha chain, MHC class II antigen DMA, class II histocompatibility antigen, M alpha chain, really interesting new gene 6 protein, D6S222E, DMA, HLADM, RING6,)
- NCBI Gene ID:
3108
- Species:
Homo sapiens (Human)
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UNIPROT ID#>>Q31604
UNIPROT ID#>>Q6ICR9
- View the NCBI Database
for this Gene »
Gene products are often involved in multiple pathways and networks within a living
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major histocompatibility complex, class II, DM alpha interacts with:
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this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see
how a sequence matches to an experimentally-validated ORF clone.
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