HMGB3, high mobility group box 3

HMGB3, high mobility group box 3

• This gene encodes a member of a family of proteins containing one or more high mobility group DNA-binding motifs. The encoded protein plays an important role in maintaining stem cell populations, and may be aberrantly expressed in tumor cells. A mutation in this gene was associated with microphthalmia, syndromic 13. There are numerous pseudogenes of this gene on multiple chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

• Gene Synonyms (high mobility group protein B3, high mobility group protein 2a, high-mobility group (nonhistone chromosomal) protein 4, HMG-2a, HMG-4, HMG2A, HMG4,)
• NCBI Gene ID: 3149
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O15347
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

high mobility group box 3 interacts with:

• 3'-phosphoadenosine 5'-phosphosulfate synthase 1
  cullin associated and neddylation dissociated 1
  DEAD-box helicase 19A
  density regulated re-initiation and release factor
  exosome component 4
  G3BP stress granule assembly factor 1
  H3 clustered histone 1
  HEXIM P-TEFb complex subunit 1
  high mobility group AT-hook 1
  importin 9
  La ribonucleoprotein 7, transcriptional regulator
  lamin A/C
  MCTS1 re-initiation and release factor
  mesenchyme homeobox 1
  mesenchyme homeobox 2
  Mov10 RISC complex RNA helicase
  nuclear casein kinase and cyclin dependent kinase substrate 1
  nuclear RNA export factor 1
  paired box 5
  paired box 6
  platelet activating factor acetylhydrolase 1b regulatory subunit 1
  protein disulfide isomerase family A member 4
  secernin 1
  SPT16 homolog, facilitates chromatin remodeling subunit
  structure specific recognition protein 1
  succinate dehydrogenase complex flavoprotein subunit A
  superoxide dismutase 1
  syndecan binding protein
  TERF2 interacting protein
  transcription factor AP-4
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta
  UBX domain protein 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.