IGFBP3, insulin like growth factor binding protein 3

IGFBP3, insulin like growth factor binding protein 3

• This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

• Gene Synonyms (insulin-like growth factor-binding protein 3, IBP-3, IGF-binding protein 3, IGFBP-3, acid stable subunit of the 140 K IGF complex, binding protein 29, binding protein 53, growth hormone-dependent binding protein, BP-53, IBP3,)
• NCBI Gene ID: 3486
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B3KPF0
  UNIPROT ID#>>P17936
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

insulin like growth factor binding protein 3 interacts with:

• ADAM metallopeptidase domain 12
  DNA polymerase alpha 2, accessory subunit
  insulin-like growth factor 2
  kallikrein B1
  karyopherin subunit beta 1
  latent transforming growth factor beta binding protein 1
  latent transforming growth factor beta binding protein 1
  matrix metallopeptidase 1
  matrix metallopeptidase 2
  matrix metallopeptidase 3
  pappalysin 2
  peroxisome proliferator activated receptor gamma
  plasminogen
  retinoid X receptor alpha
  transferrin

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.