ITGAE, integrin subunit alpha E

ITGAE, integrin subunit alpha E

• Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, this protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. This protein is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation. [provided by RefSeq, Jul 2008]

• Gene Synonyms (CD103, HUMINAE, integrin alpha-E, HML-1 antigen, antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide, human mucosal lymphocyte antigen 1, alpha polypeptide, integrin alpha-IEL, integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide), mucosal lymphocyte 1 antigen,)
• NCBI Gene ID: 3682
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P38570
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

integrin subunit alpha E interacts with:

• checkpoint with forkhead and ring finger domains
  embryonic ectoderm development
  integrin subunit beta 7
  ring finger protein 123
  tripartite motif containing 25

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.