KCNJ11, potassium inwardly rectifying channel subfamily J member 11

KCNJ11, potassium inwardly rectifying channel subfamily J member 11

• Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM). Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2009]

• Gene Synonyms (BIR, HHF2, IKATP, KIR6.2, MODY13, PHHI, PNDM2, TNDM3, ATP-sensitive inward rectifier potassium channel 11, beta-cell inward rectifier subunit, inward rectifier K(+) channel Kir6.2, inwardly rectifing potassium channel subfamily J member 11, inwardly rectifying potassium channel KIR6.2, inwardly-rectifying potassium channel subfamily J member 11, potassium channel inwardly rectifing subfamily J member 11, potassium channel, inwardly rectifying subfamily J member 11, potassium voltage-gated channel subfamily J member 11,)
• NCBI Gene ID: 3767
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B2RC52
  UNIPROT ID#>>Q14654
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

potassium inwardly rectifying channel subfamily J member 11 interacts with:

• ATP binding cassette subfamily C member 8
  ATP binding cassette subfamily C member 9
  exosome component 8
  glycerophosphodiester phosphodiesterase domain containing 5
  interleukin 17 receptor C
  lactate dehydrogenase A
  MINDY lysine 48 deubiquitinase 2
  protocadherin alpha subfamily C, 2
  protocadherin beta 16
  solute carrier family 17 member 2
  transient receptor potential cation channel subfamily M member 8
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.