M6PR, mannose-6-phosphate receptor, cation dependent

M6PR, mannose-6-phosphate receptor, cation dependent

• This gene encodes a member of the P-type lectin family. P-type lectins play a critical role in lysosome function through the specific transport of mannose-6-phosphate-containing acid hydrolases from the Golgi complex to lysosomes. The encoded protein functions as a homodimer and requires divalent cations for ligand binding. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome X. [provided by RefSeq, May 2011]

• Gene Synonyms (CD-M6PR, CD-MPR, MPR 46, MPR-46, MPR46, SMPR, cation-dependent mannose-6-phosphate receptor, 46-kDa mannose 6-phosphate receptor, CD Man-6-P receptor, Mr 46,000 Man6PR, small mannose 6-phosphate receptor,)
• NCBI Gene ID: 4074
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P20645
  UNIPROT ID#>>F5GX30
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

mannose-6-phosphate receptor, cation dependent interacts with:

• 4-hydroxyphenylpyruvate dioxygenase like
  agrin
  cytochrome b5 type B
  dual specificity phosphatase 12
  F-box protein 6
  golgi associated, gamma adaptin ear containing, ARF binding protein 1
  golgi associated, gamma adaptin ear containing, ARF binding protein 2
  golgi associated, gamma adaptin ear containing, ARF binding protein 3
  GTPase, IMAP family member 5
  heat shock protein family A (Hsp70) member 12A
  Mov10 RISC complex RNA helicase
  NADH:ubiquinone oxidoreductase subunit B4
  NADH:ubiquinone oxidoreductase subunit S4
  ninjurin 2
  nuclear RNA export factor 1
  paraoxonase 2
  perilipin 3
  RAN binding protein 2
  renin
  ribosomal protein L37a
  ribosomal protein L6
  ribosomal protein S28
  ring finger protein 4
  single-pass membrane protein with coiled-coil domains 4
  synaptojanin 2 binding protein
  TAFA chemokine like family member 1
  TAFA chemokine like family member 4
  translocase of outer mitochondrial membrane 22

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.