SMAD5, SMAD family member 5

SMAD5, SMAD family member 5

• The protein encoded by this gene is involved in the transforming growth factor beta signaling pathway that results in an inhibition of the proliferation of hematopoietic progenitor cells. The encoded protein is activated by bone morphogenetic proteins type 1 receptor kinase, and may be involved in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

• Gene Synonyms (DWFC, JV5-1, MADH5, mothers against decapentaplegic homolog 5, MAD, mothers against decapentaplegic homolog 5, SMA- and MAD-related protein 5, SMAD, mothers against DPP homolog 5, mothers against decapentaplegic, drosophila, homolog of, 5,)
• NCBI Gene ID: 4090
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q68DB7
  UNIPROT ID#>>Q99717
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

SMAD family member 5 interacts with:

• ankyrin repeat domain 13A
  charged multivesicular body protein 3
  COP9 signalosome subunit 5
  CXXC finger protein 5
  epsin 1
  exportin 1
  growth differentiation factor 6
  HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
  hepatocyte growth factor-regulated tyrosine kinase substrate
  high mobility group AT-hook 2
  inositol-pentakisphosphate 2-kinase
  lipolysis stimulated lipoprotein receptor
  menin 1
  methyl-CpG binding domain protein 1
  myotubularin related protein 10
  N-alpha-acetyltransferase 20, NatB catalytic subunit
  NEDD4 E3 ubiquitin protein ligase
  paired box 6
  peptidylprolyl isomerase like 4
  pleckstrin homology domain containing A4
  pleckstrin homology domain containing O1
  polynucleotide kinase 3'-phosphatase
  POU class 6 homeobox 2
  proteasome 26S subunit, non-ATPase 11
  protein tyrosine phosphatase non-receptor type 12
  RNA binding motif protein 4
  ryanodine receptor 2
  serine rich single-pass membrane protein 1
  SKI proto-oncogene
  SMAD family member 6
  SMAD specific E3 ubiquitin protein ligase 1
  SMAD specific E3 ubiquitin protein ligase 2
  small nuclear ribonucleoprotein polypeptide A
  small nuclear ribonucleoprotein U1 subunit 70
  splicing factor 3b subunit 1
  splicing factor 3b subunit 3
  splicing factor proline and glutamine rich
  SRY-box transcription factor 5
  SRY-box transcription factor 7
  STIP1 homology and U-box containing protein 1
  suppressor of variegation 3-9 homolog 1
  suppressor of variegation 3-9 homolog 2
  transducer of ERBB2, 1
  U2 small nuclear RNA auxiliary factor 2
  ubiquitin like modifier activating enzyme 1
  WW domain binding protein 2
  WW domain containing E3 ubiquitin protein ligase 1
  Yes1 associated transcriptional regulator
  zinc finger E-box binding homeobox 2
  zinc finger protein 128
  zinc finger protein 8

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.