MFGE8, milk fat globule EGF and factor V/VIII domain containing

MFGE8, milk fat globule EGF and factor V/VIII domain containing

• This gene encodes a preproprotein that is proteolytically processed to form multiple protein products. The major encoded protein product, lactadherin, is a membrane glycoprotein that promotes phagocytosis of apoptotic cells. This protein has also been implicated in wound healing, autoimmune disease, and cancer. Lactadherin can be further processed to form a smaller cleavage product, medin, which comprises the major protein component of aortic medial amyloid (AMA). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]

• Gene Synonyms (BA46, EDIL1, HMFG, HsT19888, MFG-E8, MFGM, OAcGD3S, SED1, SPAG10, hP47, lactadherin, O-acetyl disialoganglioside synthase, breast epithelial antigen BA46, medin, milk fat globule-EGF factor 8 protein, sperm associated antigen 10, sperm surface protein hP47,)
• NCBI Gene ID: 4240
• Species: Homo sapiens (Human)
• UNIPROT ID#>>F5GZN3
  UNIPROT ID#>>B4E396
  UNIPROT ID#>>X6R3G6
  UNIPROT ID#>>Q08431
  UNIPROT ID#>>B3KTQ2
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

milk fat globule EGF and factor V/VIII domain containing interacts with:

• ATP binding cassette subfamily E member 1
  metadherin
  platelet derived growth factor receptor beta
  testis expressed 101
  YTH N6-methyladenosine RNA binding protein 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.