MMP17, matrix metallopeptidase 17

MMP17, matrix metallopeptidase 17

• This gene encodes a member of the peptidase M10 family and membrane-type subfamily of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Members of this subfamily contain a transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. The encoded preproprotein is proteolytically processed to generate the mature protease. This protein is unique among the membrane-type matrix metalloproteinases in that it is anchored to the cell membrane via a glycosylphosphatidylinositol (GPI) anchor. Elevated expression of the encoded protein has been observed in osteoarthritis and multiple human cancers. [provided by RefSeq, Jan 2016]

• Gene Synonyms (MMP-17, MT4-MMP, MT4MMP, MTMMP4, matrix metalloproteinase-17, MT-MMP 4, matrix metallopeptidase 17 (membrane-inserted), matrix metalloproteinase 17 (membrane-inserted), membrane-type matrix metalloproteinase 4, membrane-type-4 matrix metalloproteinase,)
• NCBI Gene ID: 4326
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9ULZ9
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

matrix metallopeptidase 17 interacts with:

• tripartite motif containing 25
  tumor necrosis factor

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