NEK1, NIMA related kinase 1

NEK1, NIMA related kinase 1

• The protein encoded by this gene is a serine/threonine kinase involved in cell cycle regulation. The encoded protein is found in a centrosomal complex with FEZ1, a neuronal protein that plays a role in axonal development. Defects in this gene are a cause of polycystic kidney disease (PKD). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2010]

• Gene Synonyms (ALS24, NY-REN-55, SRPS2, SRPS2A, SRTD6, serine/threonine-protein kinase Nek1, NIMA (never in mitosis gene a)-related kinase 1, never in mitosis A-related kinase 1, nimA-related protein kinase 1, protein-serine/threonine kinase, renal carcinoma antigen NY-REN-55,)
• NCBI Gene ID: 4750
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q5JXL9
  UNIPROT ID#>>Q96PY6
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

NIMA related kinase 1 interacts with:

• alsin Rho guanine nucleotide exchange factor ALS2
  catenin alpha like 1
  centromere protein E
  centrosomal protein 104
  centrosomal protein 104
  centrosomal protein 290
  copine 2
  CTD small phosphatase 2
  exosome component 4
  exportin 1
  fasciculation and elongation protein zeta 1
  fasciculation and elongation protein zeta 2
  kinesin family member 2B
  kinesin family member 3A
  leucine rich repeat kinase 1
  leucine rich repeat kinase 2
  malignant fibrous histiocytoma amplified sequence 1
  NIMA related kinase 5
  protein phosphatase 2 regulatory subunit B'alpha
  protein phosphatase 2 regulatory subunit B'delta
  protein tyrosine phosphatase receptor type D
  RPGRIP1 like
  signal regulatory protein alpha
  spermatogenesis associated 7
  src kinase associated phosphoprotein 1
  tektin 4
  tetratricopeptide repeat domain 25
  TSC complex subunit 2
  tumor protein p53 binding protein 1
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta
  vitronectin
  VPS26, retromer complex component B
  WD repeat domain 83
  zinc finger protein 350

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.