NFKBIE, NFKB inhibitor epsilon

NFKBIE, NFKB inhibitor epsilon

• The protein encoded by this gene binds to components of NF-kappa-B, trapping the complex in the cytoplasm and preventing it from activating genes in the nucleus. Phosphorylation of the encoded protein targets it for destruction by the ubiquitin pathway, which activates NF-kappa-B by making it available to translocate to the nucleus. [provided by RefSeq, Sep 2011]

• Gene Synonyms (IKBE, NF-kappa-B inhibitor epsilon, I-kappa-B-epsilon, NF-kappa-BIE, ikB-E, ikB-epsilon, ikappaBepsilon, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon,)
• NCBI Gene ID: 4794
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O00221
  UNIPROT ID#>>A0A024RD24
  UNIPROT ID#>>Q96F31
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

NFKB inhibitor epsilon interacts with:

• ankyrin repeat and KH domain containing 1
  beta-transducin repeat containing E3 ubiquitin protein ligase
  cullin 1
  exportin 1
  histone deacetylase 4
  histone deacetylase 5
  hook microtubule tethering protein 1
  hypoxia inducible factor 1 subunit alpha inhibitor
  kelch repeat and BTB domain containing 7
  nuclear receptor corepressor 2
  pre-mRNA processing factor 4
  protein phosphatase 6 catalytic subunit
  REL proto-oncogene, NF-kB subunit
  RELA proto-oncogene, NF-kB subunit
  RELB proto-oncogene, NF-kB subunit
  S-phase kinase associated protein 1
  spindle and kinetochore associated complex subunit 3
  TPX2, microtubule-associated
  ubiquitin protein ligase E3 component n-recognin 5
  YEATS domain containing 4

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.