PRELP, proline and arginine rich end leucine rich repeat protein

PRELP, proline and arginine rich end leucine rich repeat protein

• The protein encoded by this gene is a leucine-rich repeat protein present in connective tissue extracellular matrix. This protein functions as a molecule anchoring basement membranes to the underlying connective tissue. This protein has been shown to bind type I collagen to basement membranes and type II collagen to cartilage. It also binds the basement membrane heparan sulfate proteoglycan perlecan. This protein is suggested to be involved in the pathogenesis of Hutchinson-Gilford progeria (HGP), which is reported to lack the binding of collagen in basement membranes and cartilage. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]

• Gene Synonyms (prolargin, 55 kDa leucine-rich repeat protein of articular cartilage, prolargin proteoglycan, proline-arginine-rich end leucine-rich repeat protein, MST161, MSTP161, SLRR2A,)
• NCBI Gene ID: 5549
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P51888
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

proline and arginine rich end leucine rich repeat protein interacts with:

• collagen type XIV alpha 1 chain
  cytoskeleton associated protein 4
  dehydrogenase/reductase 4
  follistatin like 1
  nidogen 2
  protein phosphatase 2 regulatory subunit Bdelta
  tripartite motif containing 68
  tRNA splicing endonuclease subunit 2
  YTH N6-methyladenosine RNA binding protein 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.