PRSS1, serine protease 1

PRSS1, serine protease 1

• This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is secreted by the pancreas and cleaved to its active form in the small intestine. It is active on peptide linkages involving the carboxyl group of lysine or arginine. Mutations in this gene are associated with hereditary pancreatitis. This gene and several other trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7. [provided by RefSeq, Jul 2008]

• Gene Synonyms (trypsin-1, TCR V beta 4.1, beta-trypsin, cationic trypsinogen, digestive zymogen, nonfunctional trypsin 1, protease, serine 1, trypsinogen 1, trypsinogen A, TRP1, TRY1, TRY4, TRYP1,)
• NCBI Gene ID: 5644
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P07477
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

serine protease 1 interacts with:

• agrin
  cell division cycle 73
  centrosomal protein 250
  dynactin 3
  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  junction plakoglobin
  leucine rich repeat containing G protein-coupled receptor 4
  neural precursor cell expressed, developmentally down-regulated gene 1
  nuclear receptor subfamily 2 group C member 2
  proteasome 26S subunit, non-ATPase 14
  protein tyrosine phosphatase non-receptor type 4
  PTEN induced kinase 1
  ring finger protein 31
  serine peptidase inhibitor Kazal type 5
  serine/threonine kinase 38 like
  SID1 transmembrane family, member 2
  superoxide dismutase 1, soluble
  synuclein alpha
  thiosulfate sulfurtransferase
  UFM1 specific ligase 1
  VPS18 core subunit of CORVET and HOPS complexes
  WT1 associated protein

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.