KLK6, kallikrein related peptidase 6

KLK6, kallikrein related peptidase 6

• This gene encodes a member of the kallikrein subfamily of the peptidase S1 family of serine proteases. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. The encoded preproprotein is proteolytically processed to generate the mature protease. Expression of this protease is regulated by steroid hormones and may be elevated in multiple human cancers and in serum from psoriasis patients. The encoded protease may participate in the cleavage of amyloid precursor protein and alpha-synuclein, thus implicating this protease in Alzheimer's and Parkinson's disease, respectively. This gene is located in a gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]

• Gene Synonyms (kallikrein-6, kallikrein 6, neurosin, protease M, serine protease 18, serine protease 9, zyme, Bssp, Klk7, PRSS18, PRSS9, SP59, hK6,)
• NCBI Gene ID: 5653
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024R4J8
  UNIPROT ID#>>Q92876
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

kallikrein related peptidase 6 interacts with:

• chromodomain Y like
  cleavage and polyadenylation specific factor 4
  ER membrane protein complex subunit 7
  F-box protein 42
  partner and localizer of BRCA2
  spermatid perinuclear RNA binding protein
  synuclein alpha
  tubulin alpha 4a
  tubulin beta 3 class III
  tumor susceptibility 101

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.