HTRA1, HtrA serine peptidase 1

HTRA1, HtrA serine peptidase 1

• This gene encodes a member of the trypsin family of serine proteases. This protein is a secreted enzyme that is proposed to regulate the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. It has also been suggested to be a regulator of cell growth. Variations in the promoter region of this gene are the cause of susceptibility to age-related macular degeneration type 7. [provided by RefSeq, Jul 2008]

• Gene Synonyms (serine protease HTRA1, IGFBP5-protease, high-temperature requirement A serine peptidase 1, protease, serine, 11 (IGF binding), ARMD7, CADASIL2, CARASIL, HtrA, L56, ORF480, PRSS11,)
• NCBI Gene ID: 5654
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q92743
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

HtrA serine peptidase 1 interacts with:

• chromodomain Y like
  cytochrome c oxidase subunit 5A
  defensin beta 127
  dickkopf like acrosomal protein 1
  family with sequence similarity 107 member A
  FCH and double SH3 domains 2
  golgi transport 1B
  growth differentiation factor 5
  LDL receptor related protein 10
  MGAT4 family member C
  par-6 family cell polarity regulator beta
  regenerating family member 4
  ribosomal protein S6 kinase A1
  serine peptidase inhibitor Kazal type 4
  SREBF pathway regulator in golgi 1
  terminal nucleotidyltransferase 5A
  transmembrane protein 25

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.