PSG2, pregnancy specific beta-1-glycoprotein 2

PSG2, pregnancy specific beta-1-glycoprotein 2

• The human pregnancy-specific glycoproteins (PSGs) are a family of proteins that are synthesized in large amounts by placental trophoblasts and released into the maternal circulation during pregnancy. Molecular cloning and analysis of several PSG genes has indicated that the PSGs form a subgroup of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily of genes. Members of the CEA family consist of a single N domain, with structural similarity to the immunoglobulin variable domains, followed by a variable number of immunoglobulin constant-like A and/or B domains. Most PSGs have an arg-gly-asp (RGD) motif, which has been shown to function as an adhesion recognition signal for several integrins, in the N-terminal domain (summary by Teglund et al., 1994 [PubMed 7851896]). For additional general information about the PSG gene family, see PSG1 (MIM 176390).[supplied by OMIM, Oct 2009]

• Gene Synonyms (pregnancy-specific beta-1-glycoprotein 2, PS-beta-E, PS-beta-G-2, PSBG-2, carcinoembryonic antigen SG8, pregnancy-specific beta-1 glycoprotein E, pregnancy-specific beta-1-glycoprotein 7, pregnancy-specific glycoprotein 2, CEA, PSBG2, PSG1,)
• NCBI Gene ID: 5670
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024R0M4
  UNIPROT ID#>>P11465
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

pregnancy specific beta-1-glycoprotein 2 interacts with:

• PWP1 homolog, endonuclein

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