RFX1, regulatory factor X1

RFX1, regulatory factor X1

• This gene encodes a member of the regulatory factor X (RFX) family of transcription factors, which are characterized by a winged-helix DNA-binding domain. The encoded transcription factor contains an N-terminal activation domain and a C-terminal repression domain, and may activate or repress target gene expression depending on cellular context. This transcription factor has been shown to regulate a wide variety of genes involved in immunity and cancer, including the MHC class II genes and genes that may be involved in cancer progression. This gene exhibits altered expression in glioblastoma and the autoimmune disease systemic lupus erythematosis (SLE). [provided by RefSeq, Jul 2016]

• Gene Synonyms (MHC class II regulatory factor RFX1, MHC class II regulatory factor RFX, enhancer factor C, regulatory factor X, 1 (influences HLA class II expression), trans-acting regulatory factor 1, transcription factor RFX1, EFC, RFX,)
• NCBI Gene ID: 5989
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P22670
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

regulatory factor X1 interacts with:

• decapping enzyme, scavenger
  F-box and leucine rich repeat protein 3
  forkhead box J2
  heat shock protein family B (small) member 8
  inositol polyphosphate-5-phosphatase K
  MAGE family member D1
  nuclear receptor coactivator 3
  regulatory factor X2
  regulatory factor X3
  ring finger protein 4
  spermatogenesis associated 1
  SRY-box transcription factor 2
  STIP1 homology and U-box containing protein 1
  transcriptional adaptor 3
  tumor protein p53 binding protein 1
  xylosyltransferase 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.