RHD, Rh blood group D antigen

RHD, Rh blood group D antigen

• The Rh blood group system is the second most clinically significant of the blood groups, second only to ABO. It is also the most polymorphic of the blood groups, with variations due to deletions, gene conversions, and missense mutations. The Rh blood group includes this gene, which encodes the RhD protein, and a second gene that encodes both the RhC and RhE antigens on a single polypeptide. The two genes, and a third unrelated gene, are found in a cluster on chromosome 1. The classification of Rh-positive and Rh-negative individuals is determined by the presence or absence of the highly immunogenic RhD protein on the surface of erythrocytes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

• Gene Synonyms (blood group Rh(D) polypeptide, D antigen (DCS), RH polypeptide 2, Rh blood group C antigen, Rh blood group CE antigen, Rh blood group CcEe antigen, Rh blood group antigen Evans, Rh blood group, D anitgen, RhD antigen, RhD blood group antigen, RhD polypeptide, Rhesus D blood group protein, Rhesus blood group D antigen allele DIII type 7, Rhesus system D polypeptide, blood group antigen D, blood group protein RHD, rhesus D antigen, truncated Rh blood group D antigen, truncated RhD, truncated RhD antigen, truncated rhesus D, truncated rhesus blood group D antigen, CD240D, DIIIc, RH, RH30, RHCED, RHDVA(TT), RHDel, RHPII, RHXIII, Rh4, RhDCw, RhII, RhK562-II, RhPI,)
• NCBI Gene ID: 6007
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q5XLS8
  UNIPROT ID#>>Q5XLT0
  UNIPROT ID#>>Q5XLT3
  UNIPROT ID#>>Q02161
  UNIPROT ID#>>Q7RU08
  UNIPROT ID#>>B4DLT8
  UNIPROT ID#>>Q9UPC8
  UNIPROT ID#>>E7EVW1
  UNIPROT ID#>>Q1KT12
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

Rh blood group D antigen interacts with:

• bromodomain adjacent to zinc finger domain 1B
  cAMP responsive element binding protein 3 like 1
  serine rich single-pass membrane protein 1
  sodium voltage-gated channel beta subunit 3
  transmembrane protein 14B
  transmembrane protein 237

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.