CCL21, C-C motif chemokine ligand 21

CCL21, C-C motif chemokine ligand 21

• This antimicrobial gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. Similar to other chemokines the protein encoded by this gene inhibits hemopoiesis and stimulates chemotaxis. This protein is chemotactic in vitro for thymocytes and activated T cells, but not for B cells, macrophages, or neutrophils. The cytokine encoded by this gene may also play a role in mediating homing of lymphocytes to secondary lymphoid organs. It is a high affinity functional ligand for chemokine receptor 7 that is expressed on T and B lymphocytes and a known receptor for another member of the cytokine family (small inducible cytokine A19). [provided by RefSeq, Sep 2014]

• Gene Synonyms (C-C motif chemokine 21, Efficient Chemoattractant for Lymphocytes, beta chemokine exodus-2, chemokine (C-C motif) ligand 21, secondary lymphoid tissue chemokine, small inducible cytokine subfamily A (Cys-Cys), member 21, 6Ckine, CKb9, ECL, SCYA21, SLC, TCA4,)
• NCBI Gene ID: 6366
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O00585
  UNIPROT ID#>>Q6ICR7
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

C-C motif chemokine ligand 21 interacts with:

• atypical chemokine receptor 4
  chromosome 3 open reading frame 52
  clathrin heavy chain like 1
  C-X-C motif chemokine ligand 13
  insulin-like growth factor binding protein 7
  kelch like family member 22
  kelch like family member 26
  leucine rich repeat kinase 1
  orthopedia homeobox
  thyroid hormone receptor interactor 6
  transmembrane protein 107
  ubiquilin 4

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.