CCL22, C-C motif chemokine ligand 22

CCL22, C-C motif chemokine ligand 22

• This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for monocytes, dendritic cells, natural killer cells and for chronically activated T lymphocytes. It also displays a mild activity for primary activated T lymphocytes and has no chemoattractant activity for neutrophils, eosinophils and resting T lymphocytes. The product of this gene binds to chemokine receptor CCR4. This chemokine may play a role in the trafficking of activated T lymphocytes to inflammatory sites and other aspects of activated T lymphocyte physiology. [provided by RefSeq, Sep 2014]

• Gene Synonyms (C-C motif chemokine 22, CC chemokine STCP-1, MDC(1-69), chemokine (C-C motif) ligand 22, macrophage-derived chemokine, small inducible cytokine A22, small inducible cytokine subfamily A (Cys-Cys), member 22, stimulated T cell chemotactic protein 1, A-152E5.1, ABCD-1, DC/B-CK, MDC, SCYA22, STCP-1,)
• NCBI Gene ID: 6367
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O00626
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

C-C motif chemokine ligand 22 interacts with:

• CD109 molecule
  chromodomain helicase DNA binding protein 1 like
  COBW domain containing 1
  contactin associated protein family member 3B
  dipeptidyl peptidase 8
  dual serine/threonine and tyrosine protein kinase
  essential meiotic structure-specific endonuclease 1
  family with sequence similarity 118 member B
  heat shock protein family A (Hsp70) member 12A
  HECT and RLD domain containing E3 ubiquitin protein ligase 3
  integrin subunit alpha 8
  LON peptidase N-terminal domain and ring finger 2
  lysine demethylase 4A
  out at first homolog
  pitrilysin metallopeptidase 1
  protein disulfide isomerase family A member 5
  prune exopolyphosphatase 1
  selenophosphate synthetase 2
  TGF-beta activated kinase 1 (MAP3K7) binding protein 1
  tubulin beta 3 class III
  vascular cell adhesion molecule 1
  YTH N6-methyladenosine RNA binding protein 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.