ST14, ST14 transmembrane serine protease matriptase

ST14, ST14 transmembrane serine protease matriptase

• The protein encoded by this gene is an epithelial-derived, integral membrane serine protease. This protease forms a complex with the Kunitz-type serine protease inhibitor, HAI-1, and is found to be activated by sphingosine 1-phosphate. This protease has been shown to cleave and activate hepatocyte growth factor/scattering factor, and urokinase plasminogen activator, which suggest the function of this protease as an epithelial membrane activator for other proteases and latent growth factors. The expression of this protease has been associated with breast, colon, prostate, and ovarian tumors, which implicates its role in cancer invasion, and metastasis. [provided by RefSeq, Jul 2008]

• Gene Synonyms (suppressor of tumorigenicity 14 protein, membrane-type serine protease 1, prostamin, serine protease 14, serine protease TADG-15, suppression of tumorigenicity 14 (colon carcinoma), suppression of tumorigenicity 14 (colon carcinoma, matriptase, epithin), tumor associated differentially expressed gene 15 protein, ARCI11, HAI, MT-SP1, MTSP1, PRSS14, SNC19, TADG15, TMPRSS14,)
• NCBI Gene ID: 6768
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9Y5Y6
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ST14 transmembrane serine protease matriptase interacts with:

• checkpoint kinase 2
  CUB domain containing protein 1
  platelet derived growth factor C
  serine/threonine kinase 11
  transforming growth factor beta 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.