STAR, steroidogenic acute regulatory protein

STAR, steroidogenic acute regulatory protein

• The protein encoded by this gene plays a key role in the acute regulation of steroid hormone synthesis by enhancing the conversion of cholesterol into pregnenolone. This protein permits the cleavage of cholesterol into pregnenolone by mediating the transport of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane. Mutations in this gene are a cause of congenital lipoid adrenal hyperplasia (CLAH), also called lipoid CAH. A pseudogene of this gene is located on chromosome 13. [provided by RefSeq, Jul 2008]

• Gene Synonyms (steroidogenic acute regulatory protein, mitochondrial, START domain containing 1, START domain-containing protein 1, StAR related lipid transfer (START) domain containing 1, cholesterol trafficker, mitochondrial steroid acute regulatory protein, steroid acute regulatory protein, steroidogenic acute regulator, testis secretory sperm-binding protein Li 241mP, STARD1,)
• NCBI Gene ID: 6770
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q6IBK0
  UNIPROT ID#>>P49675
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

steroidogenic acute regulatory protein interacts with:

• angiotensin II receptor associated protein
  CKLF like MARVEL transmembrane domain containing 4
  coiled-coil alpha-helical rod protein 1
  diacylglycerol O-acyltransferase 2 like 6
  fasciculation and elongation protein zeta 1
  rabaptin, RAB GTPase binding effector protein 1
  syntaxin 8

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.