CILP, cartilage intermediate layer protein

CILP, cartilage intermediate layer protein

• Major alterations in the composition of the cartilage extracellular matrix occur in joint disease, such as osteoarthrosis. This gene encodes the cartilage intermediate layer protein (CILP), which increases in early osteoarthrosis cartilage. The encoded protein was thought to encode a protein precursor for two different proteins; an N-terminal CILP and a C-terminal homolog of NTPPHase, however, later studies identified no nucleotide pyrophosphatase phosphodiesterase (NPP) activity. The full-length and the N-terminal domain of this protein was shown to function as an IGF-1 antagonist. An allelic variant of this gene has been associated with lumbar disc disease. [provided by RefSeq, Sep 2010]

• Gene Synonyms (cartilage intermediate layer protein 1, cartilage intermediate layer protein 1 C1, cartilage intermediate layer protein 1 C2, cartilage intermediate layer protein, nucleotide pyrophosphohydrolase, CILP-1, HsT18872,)
• NCBI Gene ID: 8483
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O75339
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

cartilage intermediate layer protein interacts with:

• NEDD1 gamma-tubulin ring complex targeting factor

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