- Gene Overview
- Interaction Network
- Sequence Verification
ATG4D, autophagy related 4D cysteine peptidase
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Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene belongs to the autophagy-related protein 4 (Atg4) family of C54 endopeptidases. Members of this family encode proteins that play a role in the biogenesis of autophagosomes, which sequester the cytosol and organelles for degradation by lysosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
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Gene Synonyms (cysteine protease ATG4D, APG4 autophagy 4 homolog D, ATG4 autophagy related 4 homolog D, AUT-like 4 cysteine endopeptidase, autophagin-4, autophagy-related cysteine endopeptidase 4, autophagy-related protein 4 homolog D, cysteine protease involved in autophagy, APG4-D, APG4D, AUTL4,)
- NCBI Gene ID:
84971
- Species:
Homo sapiens (Human)
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UNIPROT ID#>>B4DGM8
UNIPROT ID#>>Q86TL0
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for this Gene »
Gene products are often involved in multiple pathways and networks within a living
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autophagy related 4D cysteine peptidase interacts with:
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