B4GALT6, beta-1,4-galactosyltransferase 6

B4GALT6, beta-1,4-galactosyltransferase 6

• This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes in human. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. This gene produces multiple protein isoforms - some of which are predicted to lack the N-terminal hydrophobic signal sequence and transmembrane domain. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The canonical enzyme encoded by this gene is a lactosylceramide synthase important for glycolipid biosynthesis. [provided by RefSeq, Jan 2020]

• Gene Synonyms (beta-1,4-galactosyltransferase 6, UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 6, UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6, UDP-Gal:glucosylceramide beta-1,4-galactosyltransferase, UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 6, beta-1,4-GalTase 6, beta4GalT-VI, glucosylceramide beta-1,4-galactosyltransferase, lacCer synthase, lactosylceramide synthase, B4Gal-T6, beta4Gal-T6,)
• NCBI Gene ID: 9331
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q8WZ95
  UNIPROT ID#>>Q59GB5
  UNIPROT ID#>>Q9UBX8
  UNIPROT ID#>>G3XA83
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

beta-1,4-galactosyltransferase 6 interacts with:

• MGAT4 family member C
  TAFA chemokine like family member 4

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.